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In this regard, can you screw into polyfilla?
Polycell Deep Gap Polyfilla is the easy way to fill deeper holes, up to 20mm, in one application. Easy to sand for a smooth finish. Fills holes up to 20mm and accepts nails or screws.
In this way, can you screw into expanding foam filler?
r896neo. as woody says you cant fix into foam but if you let it go off and then chop it out to 3 inches deep, then fill this with mortar and push your plug in while its still wet it'll give you enough grip to keep the thing quite well on.
Once epoxy hardens, holes may be drilled through the resin. Crafter site 'Little Windows,' explains "You can drill holes into or through your resin pieces. Then you can either glue in an eye-screw, or add a jump-ring or a wire through the hole. Epoxy is easy to handle too.