Asked by: Yongli Gabriela
medical health substance abuse

Does buprenorphine cross the placenta?

Last Updated: 11th March, 2020

26
Methadone or buprenorphine
Both forms of OST that are prescribed in pregnancy – the mu opioid receptor full agonist methadone and partial agonist buprenorphinecross the placenta and may have an effect on the neonate. It has been the gold standard treatment for opioid-dependent pregnant women.

Click to see full answer.

Regarding this, is Buprenorphine safe for pregnancy?

Buprenorphine (which is frequently known by its common brand name, Subutex) is a widely used opioid medication considered safe for women during pregnancy. However, little is known about how the dose of buprenorphine prescribed might affect newborn babies.

Additionally, do Opioids cross placenta? All opioids cross the placenta in significant amounts. It is 50% plasma protein-bound and crosses the placenta readily. Maximal uptake by the fetal tissues occurs 2–3 h after a maternal i.m. dose, and this is the time when neonatal respiratory depression is most likely to occur.

Subsequently, one may also ask, does Suboxone affect fetus?

The naloxone part of Suboxone can precipitate opioid withdrawal when abused, making it very risky to both the mother and the fetus during pregnancy. There is a relative lack of data on the safety of this opioid antagonist when used during pregnancy.

Does methadone cross the placenta?

Methadone maintenance, on the other hand, results in increased birth weight and gestational periods. In addition, the fetuses are not exposed to infectious diseases spread by needle sharing, which is common among heroin users. Methadone does enter the placenta and can cause dependence in the fetus.

Related Question Answers

Madalina Huse

Professional

Do all babies withdraw from Subutex?

Possibly. Studies have reported that some babies will experience neonatal abstinence syndrome (NAS) when buprenorphine is used up to the time of delivery. If needed, babies can be treated for withdrawal while in the hospital.

Wilberto Romero De Avila

Professional

What are the side effects of buprenorphine?

Commonly reported side effects of buprenorphine include: constipation, dizziness, drowsiness, headache, and nausea. Other side effects include: drug withdrawal, fatigue, vomiting, hyperhidrosis, and xerostomia. See below for a comprehensive list of adverse effects.

Pepita Revidiego

Professional

What happens if you take Suboxone while pregnant?

Risks of taking Suboxone while pregnant
Babies born to mothers who have used Suboxone during pregnancy may be at greater risk of neonatal withdrawal syndrome (NAS). This syndrome occurs when pregnant women use opioids and their babies become dependent upon them.

Sukeina Bazikov

Explainer

Why is naloxone bad for pregnancy?

That can have a harmful effect on the baby's development. Naloxone helps return breathing to normal. It can also put the mother into withdrawal. The effects of opioid withdrawal while pregnant are not well understood, but it is possible that it can increase the chance for preterm delivery.

Rahima Lario

Explainer

What drugs are newborns tested for at birth?

Table 1
Drug Possible effects on the newborn
Heroin, morphine, codeine, oxycodone, hydrocodone, meperidine, fentanyl, (and others) Low birth weight [8, 9] Neonatal Abstinence Syndrome (NAS) [15, 28] scoring system available: (i) CNS irritability (ii) Autonomic dysfunction (iii) Respiratory symptoms (iv) GI disturbances

Hadi Rooiakker

Explainer

How many times can narcan be given?

If the person does not respond by waking up, to voice or touch, or breathing normally another dose may be given. NARCAN Nasal Spray may be dosed every 2 to 3 minutes, if available.

Kristina Dobato

Pundit

Is it safe to take Subutex while pregnant?

Using Subutex during pregnancy also does not cause strong withdrawal symptoms in comparison with methadone. Subutex use during pregnancy is safe as far as scientists know, but research is still being done. Abusing illicit substances during pregnancy is definitely not safe, and quitting cold turkey may be harmful.

Stoyanov Hamlov

Pundit

How long does a baby go through withdrawal?

Withdrawal symptoms usually appear 1 to 7 days after birth, can be mild or severe, and usually go away by the time a baby is 6 months old.

Jiaqian Stutenbaumer

Pundit

Can Subutex cause birth defects?

NAS can also cause low birth weight, heart defects and other birth defects and developmental challenges. Because prenatal buprenorphine use can lead to NAS, the risks of taking Subutex while pregnant often outweigh the benefits.

Sevdalina Omoregie

Pundit

Will my baby withdrawal from Suboxone?

For babies whose mothers were using Suboxone, the neonatal abstinence syndrome appeared within 3 to 4 days after the baby's birth and symptoms persisted for 2 to 2.5 weeks. The good news is that Suboxone withdrawal seems to affect fewer babies and they have an easier time of it.

Draupadi Blaske

Pundit

How long do NAS babies stay in hospital?

Babies who do not need medication to control NAS may stay in the hospital for up to a week. Many babies who need medication for NAS stay in the hospital up to 3-4 weeks, and rarely some may stay longer. It all depends on how your baby responds to treatment. During your baby's hospital stay, the NAS signs will lessen.

Reed Uzhinov

Teacher

Can you give Narcan to a pregnant woman?

Use in Pregnancy
Non-teratogenic Effects: Risk-benefit must be considered before NARCAN (naloxone) is administered to a pregnant woman who is known or suspected to be opioid-dependent since maternal dependence may often be accompanied by fetal dependence.

Abdelwahed Cintora

Teacher

How do opioids affect a fetus?

Opioid exposure during pregnancy has been linked to some negative health effects for both mothers and their babies. These include maternal death and poor fetal growth, preterm birth, stillbirth, possible specific birth defects, and neonatal abstinence syndrome (see below).

Takisha Echague

Teacher

Can opioids cause birth defects?

Opioid drugs were found to raise the risk for several different types of heart defects. This class of medications more than doubled the chances of having a baby born with hypoplastic left heart syndrome. Other birth defects associated with the drugs include spina bifida, congenital glaucoma, and hydrocephaly.

Graciella Caceiro

Teacher

What pain medication is safe while pregnant?

The Use of OTC Painkillers by Pregnant Women
  • Acetaminophen, the active ingredient in Tylenol, is considered safe during pregnancy.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) include aspirin, as well as Advil or Motrin (ibuprofen) and Aleve (naproxen).

Floreal Guinard

Reviewer

What pregnancy category is Percocet?

Teratogenic Effects: Pregnancy Category C
Animal reproductive studies have not been conducted with PERCOCET. It is also not known whether PERCOCET can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity.

Zahida Gaivoo

Reviewer

Does Percocet cause birth defects?

TUESDAY, Sept. 10 (HealthDay News) -- Women taking prescription painkillers such as Oxycontin, Vicodin and Percocet early in pregnancy are twice as likely to give birth to babies with devastating neural tube defects such as spina bifida, a new study suggests.

Zarai OubiƱa

Reviewer

Can oxycodone cause birth defects?

Some studies suggest that opioids as a general group might be associated with birth defects including heart defects and cleft lip and palate. However, these and other studies have not found a specific pattern of birth defects caused by opioids.

Nassir Coro

Reviewer

How long do opioids stay in your system?

Opiates and opioids can stay in your system for up to one week. Saliva tests can detect the drugs for between 24 and 48 hours. Urine tests can detect opiates and opioids for about seven days.