Asked by: Homero Maillo
medical health cold and flu

How do NSAIDs cause heart attacks?

Last Updated: 14th March, 2020

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"It has to do with how the medicines interact with the platelets," McCarberg says. Platelets are blood cells that help the blood clot and prevent bleeding. The non-aspirin NSAIDs work on that enzyme, too, but also affect another enzyme that promotes clotting. That can lead to heart attacks and strokes.

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Besides, how do NSAIDs increase risk of heart attack?

NSAIDs may also elevate blood pressure and cause heart failure. The risk of heart attack and stroke achieved special notoriety with rofecoxib (Vioxx), a type of NSAID called a COX-2 inhibitor. The risk increases with higher doses of NSAIDs taken for longer periods of time.

One may also ask, why is ibuprofen bad for your heart? That said, doctors have actually known for years that taking nonsteroidal anti-inflammatory medications (NSAIDs)—including ibuprofen and naproxen—may increase risk of heart attack and stroke. And if you take NSAIDs at higher dosages, you may also be more vulnerable.

Beside above, how do NSAIDs affect your heart?

Nonsteroidal anti-inflammatory drugs (NSAIDs) — medications commonly used to treat pain and inflammation — can increase the risk of a heart attack or stroke. Taking NSAIDs once in a while or for a short time, such as to help with pain due to an injury, generally has only a small risk.

Which Nsaid is safest for heart?

Starting with a 100- to 200-mg dose of celecoxib may be the safest choice in patients with CV disease. If celecoxib does not produce adequate pain relief, naproxen or ibuprofen should be considered.

Related Question Answers

Yaron Zouhair

Professional

Are there any anti inflammatory drugs that are not NSAIDs?

Acetaminophen (Tylenol®) is not an NSAID. It's a pain reliever and fever reducer but doesn't have anti-inflammatory properties of NSAIDs. However, acetaminophen is sometimes combined with aspirin in over-the-counter products, such as some varieties of Excedrin®.

Gyorgy Raguso

Professional

Why Ibuprofen is bad for you?

Ibuprofen and other NSAIDs block prostaglandins, natural body chemicals that normally dilate blood vessels leading to the kidneys. Blocking prostaglandins may lead to decreased blood flow to the kidneys, which means a lack of oxygen to keep the kidneys alive. That can cause acute kidney injury.

America Collins

Professional

What pain reliever is safe for heart patients?

Acetaminophen Is the Best Pain Reliever for Heart Patients
That's because acetaminophen is unlike other common, over-the-counter pain medications, like ibuprofen and naproxen, which can aggravate high blood pressure, and in turn raise a person's risk of having a heart attack. Those drugs can also cause fluid retention.

Grit Anoch

Explainer

Why are NSAIDs bad for you?

NSAIDs have other dangers, too. They can cause high blood pressure and kidney damage in some people. They can also cause potentially severe allergic reactions. Both prescription and over-the-counter NSAIDs now carry warnings about skin reactions as well.

Robertina

Explainer

Why is rofecoxib banned?

In September 2004, Merck voluntarily withdrew rofecoxib from the market because of concerns about increased risk of heart attack and stroke associated with long-term, high-dosage use. Rofecoxib was one of the most widely used drugs ever to be withdrawn from the market.

Karamjit Kreuzberg

Explainer

What is the safest anti inflammatory medication?

At the drugstore, the most common alternatives to acetaminophen are ibuprofen (brand names Advil and Motrin) and naproxen (brand names Aleve, Naprosyn, and Anaprox). Both of these are part of a class of drugs known as non-steroidal anti-inflammatory drugs (NSAIDs). Many people are familiar with these medications.

Samatha Lawerentz

Pundit

Is Aleve safe for heart patients?

Naproxen sodium, the active ingredient in Aleve, may have a lower risk of heart attack and stroke than ibuprofen, but to date, there is no conclusive evidence to support this supposition.

Valery Penchev

Pundit

Are NSAIDs safe to take daily?

The bottom line. NSAIDs can be remarkably helpful medications, but they can cause trouble. The risk of serious side effects goes up when taken in higher than recommended doses. Except for low-dose aspirin (commonly taken to prevent heart attack or stroke), NSAIDs are taken primarily to relieve symptoms of pain or fever

Milan Ibba

Pundit

What is the strongest Nsaid?

Diclofenac is the Most Effective NSAID in Reducing Osteoarthritic Pain. While diclofenac is the most effective NSAID for treating osteoarthritic pain, clinicians need to be aware of its potential harmful effects.

Adrian Reimersdahl

Pundit

Can aspirin stop a heart attack?

Aspirin interferes with your blood's clotting action. Then, a blood clot can quickly form and block the artery. This prevents blood flow to the heart and causes a heart attack. Aspirin therapy reduces the clumping action of platelets — possibly preventing a heart attack.

Evdochia Asia

Pundit

How much ibuprofen is safe long term?

Do not take more than your recommended dose. An ibuprofen overdose can damage your stomach or intestines. The maximum amount of ibuprofen for adults is 800 milligrams per dose or 3200 mg per day (4 maximum doses). Use only the smallest amount needed to get relief from your pain, swelling, or fever.

Salimu Wiesendahl

Teacher

How dangerous is naproxen?

Naproxen may raise your risk for heart attacks and stroke. Heart and stroke risk is greater if you have a history of or risk factors for heart disease. Naproxen may cause ulcers and bleeding in your gastrointestinal (GI) tract. Ulcer and bleeding risk is higher if you are elderly.

Raman Oyono

Teacher

Is ibuprofen bad for your kidneys?

Heavy or long-term use of some of these medicines, such as ibuprofen, naproxen, and higher dose aspirin, can cause chronic kidney disease known as chronic interstitial nephritis. If you have decreased kidney function, painkillers called NSAIDs (see below) and higher dose aspirin are not recommended.

Ninel TantiƱa

Teacher

How dangerous is indomethacin?

Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID). NSAIDs may increase your risk of heart attack, heart failure, or stroke. This risk may be higher if you're taking it long term, at high doses, or if you already have heart problems or risk factors for heart disease, such as high blood pressure.

Giorgina Wilde

Teacher

Can NSAIDs cause heart palpitations?

Although effective for pain relief, some non-steroidal anti-inflammatory drugs (NSAIDs) carry the risk of atrial fibrillation among older adults, the study found. Irregular heartbeats can lead to a number of problems including dizziness, shortness of breath, fatigue and heart palpitations.

Yuhong Rybacki

Reviewer

What are the side effects of taking ibuprofen long term?

Long-term effects
Regular use of ibuprofen may eventually cause: kidney and liver damage. bleeding in the stomach and bowels. increased risk of heart attack.

Eleuterio Duchscherer

Reviewer

What are the side effects of NSAIDs?

Common side effects of NSAIDs include:
  • Stomach pain and heartburn.
  • Stomach ulcers.
  • A tendency to bleed more, especially when taking aspirin.
  • Headaches and dizziness.
  • Ringing in the ears.
  • Allergic reactions such as rashes, wheezing, and throat swelling.
  • Liver or kidney problems.
  • High blood pressure.

Latisha Beloglazov

Reviewer

Which is safer Tylenol or ibuprofen?

Is acetaminophen safer than ibuprofen? Acetaminophen is easier on the stomach than NSAIDs, but it can cause liver damage if you take more than it says on the instructions, particularly if you drink alcohol.

Mohan Canova

Reviewer

Is it harmful to take ibuprofen every day?

A: Taking 800 mg three times a day of ibuprofen is okay for a short period of time, a month or two, or even longer if under supervision of a physician. The only issue is if there is a history of heart disease, the patient should not take it over six weeks.