Asked by: Pepa Kettelakemedical health pharmaceutical drugs
How do you solve the volume of a distribution?
Last Updated: 15th June, 2020
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Hereof, what is volume of distribution used for?
Volume of distribution (V) is a primary PK parameter that relates drug concentration measured in plasma or blood to the amount of drug in the body and is used to characterize drug distribution. It is a key parameter as it is a primary determinant (together with clearance) of drug half-life.
Furthermore, what is a low volume of distribution? Definition/Introduction (High Vd -> More distribution to other tissue) Conversely, a drug with a low Vd has a propensity to remain in the plasma meaning a lower dose of a drug is required to achieve a given plasma concentration. (Low Vd -> Less distribution to other tissue)
Similarly, what is a normal volume of distribution?
If the volume is between 7 4 and 15 7 L, the drug is thought to be distributed throughout the blood (plasma and red blood cells). If the volume of distribution is larger than 42, the drug is thought to be distributed to all tissues in the body, especially the fatty tissue.
How does volume of distribution affect half life?
In brief : Half-life (t½) is the time required to reduce the concentration of a drug by half. The formula for half-life is (t½ = 0.693 × Vd /CL) renal failure with oedema) volume of distribution increases but clearance decreases, resulting in an unchanged half life (thus, it is a poor measure of drug clearance alone).