Asked by: Carlitos Galdurozmedical health diabetes
How does fructose 1 phosphate inhibit Glycogenolysis?
Last Updated: 14th January, 2020
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In this regard, why is fructose 1 phosphate accumulation?
The accumulation of fructose 1-phosphate resulted in glycogen synthesis in the liver by inducing the enzymic activity of glycogen synthase b in the presence of glucose 6-phosphate in vivo and by promoting the activation of glycogen synthase.
Subsequently, question is, why does fructose intolerance cause hyperuricemia? Fructose-induced hyperuricemia: observations in normal children and in patients with hereditary fructose intolerance and galactosemia. In two patients with HFI the uric acid excretion increased four- to fivefold after fructose administration; the increased uric acid excretion in HFI exceeded that of normal children.
Furthermore, how does fructose intolerance cause hypoglycemia?
Hereditary fructose intolerance is an inborn error of metabolism with autosomal recessive inheritance. l-Sorbose is poorly metabolized by these patients but it does not induce hypoglycemia or hypophosphatemia. Hypoglycemia after the administration of fructose or sorbitol is due to a block of hepatic glucose release.
What is Fructosemia?
Hereditary fructosemia, also termed hereditary fructose intolerance, is an autosomal recessive deficiency of aldo-lase B (fructose biphosphate aldolase) in the liver, kidney, and intestines. 4. Mutations occur in the aldolase B gene, located on chromosome 9q22.