Asked by: Adorinda Tihyhealthy living nutrition
How is pyruvate converted to Oxaloacetate?
Last Updated: 24th April, 2020
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Similarly one may ask, which coenzyme is required for the conversion of pyruvate to oxaloacetate?
acetyl Coenzyme A
what makes Oxaloacetate? A pyruvate molecule is carboxylated by a pyruvate carboxylase enzyme, activated by a molecule each of ATP and water. This reaction results in the formation of oxaloacetate. NADH reduces oxaloacetate to malate. This transformation is needed to transport the molecule out of the mitochondria.
Herein, how is Oxaloacetate used in gluconeogenesis?
Gluconeogenesis begins in the mitochondria with the formation of oxaloacetate by the carboxylation of pyruvate. This reaction also requires one molecule of ATP, and is catalyzed by pyruvate carboxylase. Oxaloacetate is decarboxylated and then phosphorylated to form phosphoenolpyruvate using the enzyme PEPCK.
Which amino acids are converted to Oxaloacetate?
Aspartate and asparagine are converted into oxaloacetate, a citric acid cycle intermediate. Aspartate, a four-carbon amino acid, is directly transaminated to oxaloacetate.