Asked by: Abarne Baggmedical health brain and nervous system disorders
What causes Wallerian degeneration?
Last Updated: 28th June, 2020
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Thereof, what is Wallerian degeneration?
Wallerian degeneration is an active process of degeneration that results when a nerve fiber is cut or crushed and the part of the axon distal to the injury (i.e. farther from the neuron's cell body) degenerates.
Beside above, what is the first step in Wallerian degeneration? First step of Wallerian Degeneration. myelin sheath pulls away from the segment. Second step of Wallerian Degeneration. The axon segment breaks into smaller segments.
Also, why does Wallerian degeneration occur?
Wallerian degeneration: process that occurs when a neuron is damaged so severely that part of the axon is disconnected from the soma of the neuron. The disconnected portion of the axon is degenerated and eventually the remaining debris is cleared from the nervous system through the help of glial cells.
Why is Wallerian degeneration in the CNS so slow?
In the PNS, rapid WD results in an extracellular environment that promotes axon regeneration, whereas in the mammalian CNS, slow WD results in the prolonged presence of myelin-associated in- hibitors that likely contribute to the failure of CNS axons to regenerate.