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In respect to this, how does Iago manipulate Cassio?
Iago manipulates Cassio by convincing Cassio to drink, knowing that Cassio vulnerability is getting mouthy when he is drunk. Iago knows that this can cause Cassio to get fired. It was clear that Iago successfully used Cassio's weakness to get what he wants by getting Cassio fired because of his drunken anger.
In this regard, how does Iago convince Cassio to drink?
He tells Cassio that he suspects Desdemona to be a temptress, but Cassio maintains that she is modest. Then, despite Cassio's protestations, Iago persuades Cassio to take a drink and to invite some revelers to join them. Amidst all the drunkards, Iago will lead Cassio into committing an action that will disgrace him.
Iago manipulates the other characters of Othello by preying on and triggering their individual doubts and insecurities. He implies to Othello that his wife, Desdemona, is having an affair with Cassio, but, importantly, he makes his implications sound hesitant so that Othello is more inclined to believe him.