What does volume of distribution tell us?

Hereof, what is the significance of volume of distribution?

The volume of distribution (Vd) is a measurement of how a drug is dispersed in the body related to the measured plasma concentration. It's used to determine the loading dose of a drug, the half-life of a drug, medication clearance, and drug toxicity.

One may also ask, what does a low volume of distribution mean? Definition/Introduction Conversely, a drug with a low Vd has a propensity to remain in the plasma meaning a lower dose of a drug is required to achieve a given plasma concentration. (Low Vd -> Less distribution to other tissue)

In this regard, what does increased volume of distribution mean?

This means that most of the drug is in the tissue, and very little is in the plasma circulating. The larger the volume of distribution, the more likely that the drug is found in the tissues of the body. The smaller the volume of distribution, the more likely that the drug is confined to the circulatory system.

How does volume of distribution affect half life?

In brief : Half-life (t½) is the time required to reduce the concentration of a drug by half. The formula for half-life is (t½ = 0.693 × Vd /CL) renal failure with oedema) volume of distribution increases but clearance decreases, resulting in an unchanged half life (thus, it is a poor measure of drug clearance alone).