Asked by: Serigne Castiello
medical health skin and dermatology

What drugs can cause a positive ANA?

Last Updated: 7th February, 2020

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Positive antinuclear antibody (ANA) test result; usually antihistone antibodies.

Medications reported to have a definite relationship to DILE, based on controlled studies, include the following2:
  • Sulfadiazine.
  • Hydralazine.
  • Procainamide.
  • Isoniazid.
  • Methyldopa.
  • Quinidine.
  • Minocycline.
  • Chlorpromazine.

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Then, what can cause a positive ANA?

ANAs could signal the body to begin attacking itself which can lead to autoimmune diseases, including lupus, scleroderma, Sjögren's syndrome, polymyositis/dermatomyositis, mixed connective tissue disease, drug-induced lupus, and autoimmune hepatitis. A positive ANA can also be seen in juvenile arthritis.

is Ana positive dangerous? Introduction. The finding of antinuclear antibody (ANA) positivity in a healthy individual is usually of unknown significance and in most cases is benign. However, a subset of such individuals is at risk for development of autoimmune disease.

In this way, what are the 38 drugs that cause drug induced lupus?

The most common medicines known to cause drug-induced lupus erythematosus are:

  • Isoniazid.
  • Hydralazine.
  • Procainamide.
  • Tumor-necrosis factor (TNF) alpha inhibitors (such as etanercept, infliximab and adalimumab)
  • Minocycline.
  • Quinidine.

What is a positive ANA test?

An ANA test detects antinuclear antibodies (ANA) in your blood. In most cases, a positive ANA test indicates that your immune system has launched a misdirected attack on your own tissue — in other words, an autoimmune reaction. But some people have positive ANA tests even when they're healthy.

Related Question Answers

Malick Bakitsky

Professional

What are the symptoms of a positive ANA?

Your doctor might order an ANA test if you have symptoms of an autoimmune disease, such as:
  • Joint and/or muscle pain.
  • Tiredness.
  • Recurring or persistent fever.
  • Rash.
  • Weakness.
  • Light sensitivity.
  • Numbness and tingling in your hands or feet.
  • Hair loss.

Liguang Bienhuls

Professional

Can low vitamin D cause positive ANA?

Vitamin D deficiency was associated with an increased presence of autoantibodies in healthy controls. While vitamin D deficiency has been reported in many autoimmune diseases, this is the first observation in ANA-positive healthy individuals.

Miley Gaig

Professional

What causes a speckled ANA?

Different patterns have been associated with different autoimmune disorders, although some overlap may occur. Speckled—associated with SLE, Sjögren syndrome, scleroderma, polymyositis, rheumatoid arthritis, and mixed connective tissue disease. Nucleolar—associated with scleroderma and polymyositis.

Filipp Meijers

Explainer

Can stress cause positive ANA?

Signs of stress-related ANA reactivity were seen among connective tissue disease (CTD) patients (including patients with systemic lupus erythematosus; mixed CTD; calcinosis, Reynaud's phenomenon, esophageal motility disorders, sclerodactyly, and telangiectasia; scleroderma; and Sjögren's syndrome): 11% showed stress-

Phung Loft

Explainer

What are three examples of autoantibodies?

Examples of Autoantibodies
  • Antinuclear Antibodies (ANA)
  • Antineutrophil Cytoplasmic Antibodies (ANCA)
  • Anti-Double Stranded DNA (anti-dsDNA)
  • Anticentromere Antibodies (ACA)
  • Antihistone Antibodies.
  • Cyclic Citrullinated Peptide Antibodies (CCP)

Deborah Mitschele

Explainer

What is considered a high ANA titer?

The higher the titer, the more likely the result is a “true positive” result, meaning you have significant ANAs and an autoimmune disease. For example, for a ratio of 1:40 or 1:80, the possibility of an autoimmune disorder is considered low. A positive ANA test alone can't diagnose a specific disease.

Jeniffer Veiva

Pundit

Can leukemia cause a positive ANA?

Background: Serum antinuclear antibodies (ANAs) are positive in some patients with chronic lymphocytic leukemia (CLL), but the prognostic value of ANAs remains unknown.

Malco Brunklaus

Pundit

What is a lupus like syndrome?

Lupus Like Syndrome. Drug-induced lupus erythematosus (DIL) is a subset of lupus defined as a lupus-like syndrome that develops in temporal relation to exposure to a drug and resolves after cessation of the drug exposure.

Coraima Oyarzaval

Pundit

How do you test for drug induced lupus?

A laboratory test called the antinuclear antibody panel (ANA) is used to check your blood for histone-DNA complex antibodies. The presence of these antibodies suggests a diagnosis of drug-induced lupus. Some people who have lupus due to quinidine or hydralazine may test ANA-negative.

Lynetta Chaldymov

Pundit

How are you tested for lupus?

Blood and urine tests may include:
  1. Complete blood count. This test measures the number of red blood cells, white blood cells and platelets as well as the amount of hemoglobin, a protein in red blood cells.
  2. Erythrocyte sedimentation rate.
  3. Kidney and liver assessment.
  4. Urinalysis.
  5. Antinuclear antibody (ANA) test.

Bayron Draws

Pundit

What are the symptoms of drug induced lupus?

The symptoms of drug-induced lupus
  • muscle and joint pain sometimes with swelling.
  • flu-like symptoms of fatigue and fever.
  • serositis (inflammation around the lungs or heart that causes pain or discomfort)
  • certain laboratory test abnormalities.

Felina Ulierte

Teacher

Do Antihistamines help lupus?

Apply a broad spectrum sunscreen to avoid or minimize these rashes and corticosteroid ointments or gels as recommended by your doctor. Careful management of lupus in other parts of your body also helps. Hives or welts (urticaria) are typically treated with antihistamines, anti-serotonin drugs, and corticosteroids.

Shelena Silvarrey

Teacher

How common is drug induced lupus?

Drug-induced lupus (DIL) is one of the most widely described drug-induced rheumatologic syndromes. It has been estimated that up to 10% of systemic lupus erythematosus (SLE) cases are drug induced, which approximates to 15,000 to 30,000 cases per year.

Lorette Aberirizquieta

Teacher

Is lupus contagious through saliva?

There are instances where lupus runs in the family, but it's fairly rare. Is it contagious? Lupus isn't contagious. You can't catch it from someone, nor pass it on to someone by touching them, kissing them, having sex etc.

Pearl Fiolhais

Teacher

How long does a lupus rash last?

The rash may last a few days or several years. It can go away for a while and then come back. Sometimes DLE can cause sores in the mouth or nose. Drug-induced lupus is caused by a reaction to certain long-term prescription medicines.

Nacira Balahovsky

Reviewer

Does Pantoprazole cause lupus?

Cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE) have been reported in patients taking PPIs, including pantoprazole sodium. These events have occurred as both new onset and an exacerbation of existing autoimmune disease. The majority of PPI-induced lupus erythematous cases were CLE.

Kamalatmika Portsienko

Reviewer

What is a normal Ana level?

Normal Results
Some normal people have a low level of ANA. Thus, the presence of a low level of ANA is not always abnormal. ANA is reported as a "titer". Low titers are in the range of 1:40 to 1:60. A positive ANA test is of much more importance if you also have antibodies against the double-stranded form of DNA.

Aitxiber Abelsky

Reviewer

What is usually the first sign of lupus?

One common early symptom that can be indicative of lupus is a photosensitive rash, meaning a rash that develops in response to sun exposure, particularly on the face and upper arms, says Dr. Kramer. Other early symptoms are unexplained fever and pain, swelling, and stiffness of multiple joints.

Nana Linuesa

Reviewer

How can I reduce my Ana?

Other dietary and lifestyle measures to quell inflammation and reduce ANA levels may include: Increasing your intake of vegetables and other anti-inflammatory foods—especially leafy greens, moderate amounts of fruit, grass-fed meats, wild-caught fish, healthy fats and moderate amounts of gluten-free grains.