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SHBG levels increase with estrogenicstates (oral contraceptives), pregnancy, hyperthyroidism,cirrhosis, anorexia nervosa, and certain drugs. Polycystic OvarianSyndrome is associated with insulin resistance and excess insulinlowers SHBG, which increases free testosteronelevels.
Similarly one may ask, what causes SHBG to increase?
Increased SHBG levels may be seen in:
- Liver disease.
- Overactive thyroid (hyperthyroidism)
- Eating disorders (anorexia nervosa)
- Estrogen use (hormone replacement therapy and oralcontraceptives)
- Decreased sex hormone production in men (hypogonadism)
- Pregnancy.
Furthermore, what causes high SHBG female?
Too little testosterone in men and too muchtestosterone in women can cause problems. Thelevel of SHBG in your blood changes because of factors suchas sex and age. It can also change because of obesity, liverdisease, and hyperthyroidism.
Two studies found that 25(OH)D and SHBGwere significantly associated in men. Though no study has directlydetermined if vitamin D supplementation could increaseSHBG levels, vitamin D supplementation may be helpfulto men who have low testosterone levels.