Asked by: Nadka Behokhmah
healthy living womens health

What is bendectin used for?

Last Updated: 11th May, 2020

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"Bendectin" (Doxylamine/Dicyclomine/Pyridoxine) was widely used for the treatment of nausea and vomiting of pregnancy until 1983, when production was discontinued in the face of lawsuits alleging that the drug caused congenital malformations.

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Thereof, does bendectin cause birth defects?

In the last five years, however, Bendectin has become the imputed cause of a host of birth defects. More than 300 lawsuits are pending against the manufacturer claiming damages for deformed babies born to mothers who took the drug.

Similarly, what is debendox? Pyridoxine/doxylamine, sold under the brand name Diclectin among others, is a combination of pyridoxine hydrochloride (vitamin B6) and doxylamine succinate. It is generally used for nausea and vomiting of pregnancy (morning sickness).

Additionally, when was bendectin taken off the market?

Between 1956 and 1983, the primary treatment for nausea/vomiting of pregnancy (NVP) was Bendectin, a combination of doxylamine and pyridoxine. In 1983, it was removed from the market by the manufacturer because of litigation expense.

What drugs cause birth defects in the 70?

In November 1961, thalidomide was taken off the market due to massive pressure from the press and public. Experts estimate that the drug thalidomide led to the death of approximately 2,000 children and serious birth defects in more than 10,000 children, about 5,000 of them in West Germany.

Related Question Answers

Rute Suri

Professional

What birth defects did bendectin cause?

Butler also cited a two-month-old federally funded study indicating that women in early pregnancy who swallowed the original Bendectin tablets may have quadrupled the risk of pyloric stenosis, a birth defect of the stomach that restricts an infant's ability to eat.

Naresh Elms

Professional

Did thalidomide affect all babies?

Limbs can fail to develop properly, in some cases also eyes, ears and internal organs. No-one knows how many miscarriages the drug caused, but it's estimated that, in Germany alone, 10,000 babies were born affected by Thalidomide. Many were too damaged to survive for long. Today, fewer than 3,000 are still alive.

Garfield Kiwitz

Professional

What is teratogenic effect?

Teratogens are drugs, chemicals, or even infections that can cause abnormal fetal development. There are billions of potential teratogens, but only a few agents are proven to have teratogenic effects. These effects can result in a baby being born with a birth defect.

Shani Ahrenz

Explainer

What was the pregnancy drug that caused birth defects?

Given a life expectancy of 19 years, Mandy was one of more than 10,000 babies worldwide born with a disability caused by the drug thalidomide. Thalidomide was prescribed during pregnancy to ease morning sickness before it was withdrawn in 1961 because it was causing birth defects.

Nayib Frenz

Explainer

Is Diclectin safe for the baby?

The safety information reviewed on Diclectin and birth defects (fetal adverse events) showed no change in the safety profile of Diclectin in pregnant women. The review also concluded that the evidence continues to support Diclectin's safe and effective use for the treatment of nausea and vomiting during pregnancy.

Conversion Vagizov

Explainer

Does Diclegis affect the baby?

Studies have shown that Diclegis® presents no increased risk to an unborn baby, even when taken in the first trimester, and its combination of ingredients: is one of the most studied in pregnancy.

Publio Radetzky

Pundit

Why is doxylamine combined with pyridoxine?

This combination medication contains 2 ingredients: doxylamine and pyridoxine. It is used to prevent or reduce nausea and vomiting caused by pregnancy. Most people get enough pyridoxine in their diet, but certain health conditions (such as pregnancy, poor diet, alcoholism) can result in a lack of this vitamin.

Tammera Redecker

Pundit

Albert Jakurin

Pundit

How much Diclectin is safe?

The recommended dose is 2 tablets at bedtime.
In severe cases or if nausea or vomiting occurs during the day, your doctor may recommend adding 1 tablet in the morning and 1 tablet mid-afternoon. Swallow the medication whole.

Maryetta Litzke

Pundit

When was Diclegis introduced?

9 In April 2013, the US Food and Drug Administration (FDA) approved Diclegis® (Duchesnay USA Inc., Rosemont, PA, USA), a combination of delayed-release doxylamine succinate and pyridoxine hydrochloride, for the treatment of NVP.

Ailian Uboldi

Pundit

What class drug is Diclegis?

Doxylamine is an antihistamine that reduces the effects of natural chemical histamine in the body. Pyridoxine is a form of vitamin B (B6). Diclegis is used to treat nausea and vomiting during pregnancy, sometimes called morning sickness. Diclegis may also be used for purposes not listed in this medication guide.

Melvy Esequiel

Teacher

How does doxylamine help morning sickness?

Researchers are uncertain how the combination of vitamin B-6 and doxylamine works to treat morning sickness. This drug combination may act on neurotransmitters in the brain that trigger feelings of nausea or disrupt other bodily processes that cause vomiting.

Yohana Zelaoui

Teacher

Evi Acerete

Teacher

Is Diclegis the same as Diclectin?

Diclegis, also known as Diclectin in Canada, is the only Food and Drug Administration-approved prescription medicine for morning sickness, according to its website.

Candyce Marek

Teacher

Elody Urbanelli

Reviewer

Why is it called morning sickness?

It is called morning sickness because the symptoms are more likely to occur early in the day, but they can occur at any time. For some women, morning sickness lasts all day. The exact cause of morning sickness is not known. Most experts think changes in the woman's hormone levels during pregnancy cause it.

Trinidad Turda

Reviewer

Does Diclectin cause headaches?

But not everyone feels better, and those side effects—drowsiness, nervousness, stomach pain, headaches and irritability—can make some women feel worse. “I always felt weird and shaky on Diclectin,” Thomas recalls.

Joginder Schafft

Reviewer

Is doxylamine safe for pregnancy?

Doxylamine succinate–pyridoxine hydrochloride delayed release combination is safe and well tolerated by pregnant women when used in the recommended dose of up to 4 tablets daily in treating nausea and vomiting of pregnancy.

Sergo Scholtke

Reviewer

What is Cariban medication?

The antiemetic drug Cariban is routinely prescribed in Ireland for the symptomatic treatment of nausea and vomiting during pregnancy, and costs about €45 for a week's supply.