Asked by: Zaharie Parkermedical health pharmaceutical drugs
What is hepatic clearance?
Last Updated: 12th January, 2020
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Keeping this in consideration, how is hepatic clearance calculated?
Hepatic clearance (CLH) may be defined as the volume of blood perfusing the liver that is cleared of drug per unit time. Usually, hepatic clearance is equated with non-renal clearance and is calculated as total body clearance (CLE) minus renal clearance (CLR).
Also, what factors affect drug clearance? Factors affecting renal excretion of drugs include: kidney function, protein binding, urine pH and urine flow.
In this regard, what is drug clearance?
Drug clearance is concerned with the rate at which the active drug is removed from the body; and for most drugs at steady state, clearance remains constant so that drug input equals drug output. Clearance is defined as the rate of drug elimination divided by the plasma concentration of the drug.
How do you calculate extraction ratio?
EXTRACTION RATIO. Definition : "Rate of plasma drug removal by an organ of elimination, divided by the rate at which it is presented to this organ."