Asked by: Betsabe Cortesoo
medical health digestive disorders

What is the half life of Protonix?

Last Updated: 28th May, 2020

Pantoprazole is extensively metabolized in theliverthrough the cytochrome P-450 system, predominantly byCYP2C19demethylation with subsequent sulfation and has a serumeliminationhalf-life of about 1.1 hours. Pantoprazoledoes notaccumulate, and its pharmacokinetics are not altered bymultipledaily dosing.

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In this regard, how long does pantoprazole stay in the body?

If youbuypantoprazole from a pharmacy, you can usually take it forupto 2 weeks. After 2 weeks: if your symptoms have improved - youcantake it for another 2 weeks.

One may also ask, can you break pantoprazole in half? Take pantoprazole exactly as directed.Donot take more or less of it or take it more often or for alongerperiod of time than prescribed by your doctor. Swallow thetabletswhole; do not split, chew, or crushthem.Pantoprazole granules mixed with apple juice may begiventhrough a feeding tube.

how long should I take Protonix?


  1. For erosive esophagitis: Adults—40 milligrams (mg) onceaday for up to 8 weeks. Your doctor may want you totakepantoprazole for more than 8 weeks for certain conditions.
  2. For Zollinger-Ellison syndrome: Adults—At first,40milligrams (mg) 2 times a day. Your doctor may increase yourdoseas needed.

Can you take Protonix 40 mg twice a day?

The recommended starting dose is usually two tabletsaday. Take the two tablets 1 hour before a meal.Ifprescribed more than two tablets a day, the tabletsshouldbe taken twice daily. If your doctor prescribesadaily dose of more than four tablets a day,youwill be told exactly when to stop takingthemedicine.

Related Question Answers

Sidati Cardinho


Can you stop taking pantoprazole cold turkey?

Folks taking PPIs for treatment of stomachorduodenal ulcers for four to eight weeks do notrequiretapering down, and you can attempt to juststop them.Folks who have been taking PPIs for aperiod of six monthsmight consider tapering down their dose insteadof stopping coldturkey.

Dilyana Picaud


Can I stop taking pantoprazole suddenly?

If you don't take it or stop taking it:Ifyou don't take the drug at all or stop taking it,yourisk decreased ability to control your symptoms of GERD. Ifyoudon't take it on schedule: Not takingpantoprazoleevery day, skipping days, or taking doses atdifferent timesof day may also decrease your control ofGERD.

Bathie Schomborg


Does Pantoprazole cause stomach cancer?

Widely used PPIs include esomeprazole,lansoprazole,omeprazole, pantoprazole and rabeprazole. PPIsare used totreat acid reflux and protect the stomach lining,have beenlinked to stomach cancer before. Long-term use ofPPIs waslinked to around 4 additional stomach cancers casesper10,000 people per year.

Willette Rahil


Can you take Tums with pantoprazole?

Most people can take it without anynoticeableside effects. You can take it with aquick-actingantacid (like Maalox or Tums) ifyou needrelief right away. Unlike other proton pumpinhibitors, itcan be taken with or without food and have thesameeffectiveness.

Cassey Ubero


How long does it take for side effects to go away after stopping medication?

The medication effects could be gone eventhoughsome medication is still in your blood.Mostmedications have a half-life of about 24 hours, so theyaregone — or close to it — in 4-5 days. Afewmedications have very longhalf-lives.

Cyril Lesekrug


Does Pantoprazole make you gain weight?

Check with your doctor right away if you haveafever, joint pain, skin rash, swelling of the body, feet,orankles, or unusual weight gain afterreceivingpantoprazole. Pantoprazole may causediarrhea,and in some cases it can be severe.

Ao Fogel


How long should I take pantoprazole 40 mg?

The recommended starting dose is usually two tabletsaday. Take the two tablets 1 hour before a meal. Yourdoctormay later adjust the dose, depending on the amount of stomachacidyou produce. If prescribed more than two tablets a day, thetabletsshould be taken twice daily.

Premislao Arimon


What are the long term side effects of taking pantoprazole?

The most common side effects reportedincludeheadache, diarrhea, nausea, and vomiting. Reports of moreseriousside effects include kidney disease, fractures,infectionsand vitamin deficiencies, but these are very rare and aregenerallyassociated with long-term use (using theseproductsfor more than a year).

Xulian Luzi


What are the long term side effects of Protonix?

  • injection site reactions (redness, pain, swelling),
  • headache,
  • nausea,
  • vomiting,
  • abdominal or stomach pain,
  • diarrhea,
  • gas,
  • dizziness,

Ayuda Intxaurraga


Why would someone be on Protonix?

Pantoprazole is used to treat erosiveesophagitis(damage to the esophagus from stomach acid causedbygastroesophageal reflux disease, or GERD) in adults andchildrenwho are at least 5 years old. Pantoprazole isalsoused to treat Zollinger-Ellison syndrome and otherconditionsinvolving excess stomach acid.

Ted Denham


Does Protonix help with acid reflux?

Pantoprazole is used to treat certain stomachandesophagus problems (such as acid reflux). Ithelpsheal acid damage to the stomach and esophagus,helpsprevent ulcers, and may help prevent cancer oftheesophagus. Pantoprazole belongs to a class of drugs known asprotonpump inhibitors (PPIs).

Adair Jouannet


Is pantoprazole dangerous?

PPI have minimal side effects and few slightdruginteractions and are considered safe for long termtreatment.Pantoprazole is significantly effective both foracute andlong-term treatment with excellent control of relapse andsymptoms.It is well tolerated even for long-term therapy anditstolerability is optimal.

Lajos Nigbur


Can I drink alcohol while taking pantoprazole?

Drinking alcohol and smoking may increase acidinyour stomach. Do not drink alcohol orsmokewhile you are taking this medicine. Itmaytake several days for your stomach pain to improve. Ifyourcondition does not improve or gets worse, contactyourhealthcare provider.

Rolanda Resta


What time of day should pantoprazole be taken?

Pantoprazole tablets are taken bymouth,with or without food. Pantoprazole oralgranulesshould be taken 30 minutes before a meal. Donotcrush, chew, or break the tablet. Swallow it whole.

Imperio Gehrz


What does Generic Protonix look like?

Generic Name: pantoprazole
Pill with imprint PROTONIX is Yellow,Elliptical/ Oval and has been identified as Protonix40mg.

Arwen Hofft


What is the difference between Protonix and Prilosec?

Are Protonix and Prilosec the SameThing?Prilosec is also used to treat ulcers andfrequentheartburn. Protonix is available by prescriptionwhilePrilosec is available over-the-counter (OTC) and asageneric.

Bisma Ramsay


How do you wean off pantoprazole?

Taper off the PPI slowly.
  1. The higher the dose, the longer the taper.
  2. Decrease the current PPI dose by 50% each week until patientison the lowest dose once daily.
  3. In 2 weeks, change to H2 blocker.
  4. After 2-4 weeks on H2 blocker, try stopping or weaning.
  5. After 2 weeks off H2 blocker, try tapering offsupplements.

Ivanildo Carpallo


Can you take half a Protonix?

Administration. Caution patients that PROTONIXForDelayed-Release Oral Suspension and PROTONIXDelayed-ReleaseTablets should not be split, crushed, orchewed.PROTONIX oral suspension packet is a fixed dose andcannot bedivided to make a smaller dose.