Asked by: Wahba Tomesmedical health digestive disorders
What is the pH of pepsin?
Last Updated: 27th May, 2020
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Then, what is the optimum pH of pepsin?
One may also ask, how does pH affect pepsin? The activated enzyme then acts autocatalytically to increase the rate of formation of more pepsin. It provides the appropriate pH for the enzyme to act. The optimum pH for pepsin is approximately pH 3.5. It denatures ingested protein; denatured protein is a better substrate for the enzyme than native protein.
why does pepsin have a low pH?
The reason pepsin functions best at pH 2 is because the carboxylic acid group on the amino acid in the enzyme's active site must be in its protonated state, meaning bound to a hydrogen atom. At low pH the carboxylic acid group is protonated, which allows it to catalyze the chemical reaction of breaking chemical bonds.
What is the substrate of pepsin?
pepsin contain the aromatic amino acid residues tyrosine or phenylalanine. In the most sensitive substrates, tyrosine is combined with glutamic acid.