Asked by: Diedra Hartig
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Which antidepressants have the least side effects?

Last Updated: 27th March, 2020

These medications generally cause fewer bothersome side effects and are less likely to cause problems at higher therapeutic doses than other types of antidepressants are. SSRIs include fluoxetine (Prozac), paroxetine (Paxil, Pexeva), sertraline (Zoloft), citalopram (Celexa) and escitalopram (Lexapro).

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Regarding this, what is the best antidepressant with the least side effects?

Antidepressants with the lowest rate of sexual side effects include:

  • Bupropion (Wellbutrin XL, Wellbutrin SR)
  • Mirtazapine (Remeron)
  • Vilazodone (Viibryd)
  • Vortioxetine (Trintellix)

Subsequently, question is, what are the best antidepressants in 2018? NIHR Signal The most effective antidepressants for adults revealed in major review

  • escitalopram.
  • paroxetine.
  • sertraline.
  • agomelatine.
  • mirtazapine.

Similarly, what is the most tolerated antidepressant?

For most patients, sertraline and escitalopram are more effective and better tolerated than other antidepressants.

Six medications accounted for 90% of the prescriptions, in the following order:

  • fluoxetine (Prozac)
  • duloxetine (Cymbalta)
  • escitalopram (Lexapro)
  • paroxetine (Paxil)
  • venlafaxine (Effexor)
  • sertraline (Zoloft).

Which antidepressant medication has the least side effects in the elderly?

SSRIs considered to have the best safety profile in the elderly are citalopram, escitalopram, and sertraline.[16] These have the lowest potential for drug-drug interactions based on their cytochrome P-450 interactions.

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